NLRP3 and systemic inflammatory response syndrome: Co-localization of NLRP3 and CD31 in vascular endothelial cells of mouse lung tissue was observed after heme treatment, while no notable NLRP3 expression was observed in other cells, indicating that endothelial cells are the primary cell type contributing to pyroptosis in mice of heme-induced SIRS (Supplementary Figure S5A).