Compared to the LN-negative cases, LN patients were younger, had higher SLEDAI-2000 scores, ESR, WBC count, 24-hour urine total protein (24h-UTP), anti-dsDNA and ANA titers (AC-1 homogeneous pattern), and Cystatin-C (CysC), but lower C3 complement levels. The gene discussed is C3; the disease is lobular neoplasia.