Activated Akt promotes G1/S transition primarily by increasing Cyclin D1 expression and stability and by enhancing CDK4/6 activity, which leads to phosphorylation and functional inactivation of Rb, thereby liberating E2F transcription factors that drive S-phase gene expression (37, 44), and promoting ribosomal biosynthesis and energy metabolism by activating mTORC1, thereby providing the biomolecules required for tumor cell proliferation (45). Here, AKT1 is linked to neoplasm.