Moreover, in diabetic cardiomyopathy, O-GlcNAcylation of SNAP29 disrupts the formation of the SNAP29-STX17-VAMP8 complex that mediates autophagosome-lysosome fusion, thereby impairing autophagy-dependent degradation and exacerbating myocardial injury in type 1 diabetic rats (96). This evidence concerns the gene SNAP29 and type 1 diabetes mellitus.