Moreover, in diabetic cardiomyopathy, O-GlcNAcylation of SNAP29 disrupts the formation of the SNAP29-STX17-VAMP8 complex that mediates autophagosome-lysosome fusion, thereby impairing autophagy-dependent degradation and exacerbating myocardial injury in type 1 diabetic rats (96). Here, SNAP29 is linked to diabetic cardiomyopathy.