APOE and hyperinsulinemic hypoglycemia, familial, 4: This finding was confirmed by flow cytometry of aortas demonstrating decreased numbers of both myeloid leukocytes and macrophages in the aortic wall of Apoe/Has3-DKO mice (Figures 2G-J). Similar alterations of infiltrating immune cells in the aortic wall were observed in Has3-KO mice on a C57BL/6 background, confirming that the impaired recruitment is indeed Has3-dependent and not influenced by metabolic changes due to Apoe-deficiency (Supplementary Figures 6A-D).