SHG microscopy demonstrated that the reduced immune cell infiltration into the aortic wall of Has3-deficient mice was accompanied by fewer elastica breaks in AAA sections from Apoe/Has3-DKO vs. Apoe-KO mice after 7 days of AngII infusion (Figure 2K). Moreover, the collagen-positive area was significantly decreased in AAA tissue sections from AngII-infused Apoe/Has3-DKO as compared to Apoe-KOs mice (Figures 2L, M) suggesting also diminished collagen deposition in Has3 deficiency after 7 days of AngII infusion. The gene discussed is HAS3; the disease is triple-A syndrome.