Manna reported that L‐cysteine supplementation reduced NF‐κB phosphorylation and the secretion of TNF‐α, MCP‐1, IL‐8, IL‐1β, and IP‐10 by increasing AMPK phosphorylation and PPARγ expression against vascular inflammation in diabetes mediated by PI3K (Manna and Jain 2013). The gene discussed is IL1B; the disease is diabetes mellitus.