Additionally, uncontrolled complement activation is a key pathogenic driver in sepsis: Large amounts of anaphylatoxins such as C3a and C5a are released, activating immune cells (e.g., neutrophils and macrophages) and inducing a cytokine storm (e.g., TNF-α and IL-6) together with a thromboinflammatory response. Here, TNF is linked to Sepsis.