VWF and Sepsis: Studies have identified endothelial ADAM10 as a key nodal molecule through which certain bacteria (e.g., Staphylococcus aureus and Pseudomonas aeruginosa) precipitate microvascular injury in sepsis: Its activation dismantles the endothelial barrier, triggers von Willebrand factor (VWF) release and platelet aggregation, and ultimately precipitates organ dysfunction [33].