Notably, TGFB1, TGFB2, TGFB3, S100A8, S100A9, IL6, and PTGES secreted by PMN-MDSCs exhibit both protumorigenic and immunosuppressive properties [36,67–69], playing significant roles in promoting tumor growth and evading immune responses. The gene discussed is TGFB1; the disease is neoplasm.