CCR3 and primary cutaneous T-cell non-Hodgkin lymphoma: In Hodgkin lymphoma and cutaneous T cell lymphoma (CTCL), CCL26 recruits CCR3+ T lymphocytes into TIME, where they secrete high levels of IL-4—a hallmark of a T helper 2 (Th2)-dominant microenvironment that is closely associated with CTCL development [61].