Tumor-bearing Cx3cr1fl/flS100a8cre and Cx3cr1fl/fl mice were treated with or without αPD-1 antibody, with Cx3cr1fl/flS100a8cre mice treated with αPD-1 showing smaller tumor volumes, slower growth, and reduced tumor weights compared to those receiving single treatments (Fig. 7G to I), indicating a synergistic effect between CX3CR1 knockout and PD-1 blockade. The gene discussed is CX3CR1; the disease is neoplasm.