TIMP3 and colorectal carcinoma: The plum1 module, positively correlated with pretreatment, contained key genes such as CYP24A1,51,52FOXQ,53,54 and TIMP3. 55,56 The darkorange module, negatively correlated with pretreatment, was enriched for cell-cell interactions, with key genes including SCGN, known to promote cell apoptosis and inhibit migration/invasion in CRC cells.57