Previous studies suggest that Inhibition of BRD4 alleviates acute kidney injury-oxidative stress and apoptosis by PI3K/AKT pathway (Liu H. et al., 2019), SIRT3 via regulating autophagy and apoptosis through the PI3K/Akt pathway (Xu et al., 2021). This evidence concerns the gene AKT1 and urogenital neoplasm.