The most frequent tumor subtypes among patients with a presumed gastrointestinal origin were cholangiocarcinoma (n = 11/29; 38%) and colorectal carcinoma (n = 11/29; 38%), whereas SMARCA4-deficient non-small cell lung cancer was the most common subtype among those with a presumed pulmonary origin (n = 9/22; 41%). Here, SMARCA4 is linked to non-small cell lung carcinoma.