The top 5 positively associated proteins were olfactomedin-like protein 3 (OLFML3), insulin-like growth factor-binding protein 7 (IGFBP7), microfibril-associated glycoprotein 4 (MFAP4), angiopoietin 2 (ANGPT2), and keratocan (KERA), whereas IGFBP7,18 MFAP4,19 and ANGPT220 have been related to AF in the past. This evidence concerns the gene IGFBP7 and atrial fibrillation.