The results of the analysis with additional adjustment for potential confounding patient characteristics and comorbidities (history of diabetes mellitus, hypertension, hypercholesterolemia, and myocardial infarction; NYHA class; body mass index; and smoking status) and medication use (angiotensin-converting enzyme inhibitor, anticoagulants, aspirin, and loop diuretics) are presented in Supplemental Figure 2. This evidence concerns the gene ACE and familial hypercholesterolemia.