CHD8 and pulmonary arterial hypertension: In the PAH dataset, three genes were identified as potential biomarkers: CHD8, EIF3D, and GFM1. The evaluation of these genes showed promising results, with AUC values of 0.754 for CHD8, 0.932 for EIF3D, and 0.864 for GFM1, indicating their significant diagnostic value (Figures 10C, D).