We evaluated the differential expression of six pivotal hub genes (CHD8, DCLK1, DDX42, DHX36, EIF3D, and GFM1) within the PAH (GSE113439, GSE53408) and MDD (GSE44593, GSE54564) datasets, as shown in Figure 7. The gene discussed is DCLK1; the disease is pulmonary arterial hypertension.