In this study, we aim to elucidate the mechanistic link between the reduction of BDNF and the pathogenesis of fibrin-rich thrombi in patients with AIS and diabetes mellitus (DM) through a comprehensive analysis of thrombus ultrastructure, plasma BDNF levels, and thrombus functional properties such as permeability, polymerization, and lysis. The gene discussed is BDNF; the disease is androgen insensitivity syndrome.