BDNF and diabetes mellitus: We showed that rHu-BDNF reduced the density of fibrin fiber (p < 0.001), turbidity (p < 0.05), and maximum clot firmness (p < 0.05), while increasing the diameter of fibrin (p < 0.05), prolonging thrombin time (p < 0.001), and accelerating lysis (p < 0.001) in a concentration-dependent manner in plasma from AIS/DM patients.