Compared to the midrange group, individuals in the negative eGFRdiff group had a significantly higher odds of diabetes, even after adjusting for the creatinine-based eGFR (OR: 1.21, 95% CI: 1.08–1.36) and cystatin C-based eGFR (OR: 1.32, 95% CI: 1.16–1.50). The gene discussed is CST3; the disease is diabetes mellitus.