TREM2 and Alzheimer disease: Data from AD support the idea that TREM2 has been shown to drive the conversion of microglia into DAM that are involved in the clearance of cellular debris and maintenance of the synaptic integrity, which are critical for improving cognitive capacity (Nugent et al., 2020; Wu et al., 2022; Parhizkar et al., 2023; John et al., 2025; Zhu et al., 2025; Wu et al., 2022; Parhizkar et al., 2023; John et al., 2025; Zhu et al., 2025).