Although the latest study (Ding et al., 2022) showed SJZD exerted anti-tumor effects against GC by suppressing angiogenesis and inducing apoptosis through modulation of the PI3K/AKT pathway, these conclusions cannot fully clarify the mechanism of SJZD action on gastric cancer, because this experiment was based on immune deficient mice (NCG mice), which lack a functional adaptive immune system and thus cannot replicate the complex immunosuppressive dynamics of the human tumor microenvironment. The gene discussed is AKT1; the disease is gastric cancer.