PLA2G4A and Alzheimer disease: Notably, knockdown of cPLA2 using small interfering RNA (siRNA) counteracts the ill effects of oTau on insulin signaling in CECs by restoring the Cav-1 expression level, highlighting the pivotal role of cPLA2 activation in oTau-induced insulin signaling impairment in AD through its negative effect on Cav-1 expression.