In the central nervous system (CNS), cPLA2 activation has been implicated in processes such as neuronal excitation, synaptic secretion, apoptosis, cell-cell interactions, cognitive and behavioral functions, oxidative stress, and inflammatory responses, all of which contribute to the pathogenesis of several neurodegenerative diseases including AD (Kriem et al., 2005; Sanchez-Mejia et al., 2008; Sun et al., 2010, 2014; Hegde et al., 2023). Here, PLA2G4A is linked to Alzheimer disease.