According to research on cholinergic neurons, severe damage and early death of cholinergic neurons in the basal forebrain area can be seen as the disease progresses.16 Therefore, the main approach in treating AD is to inhibit the acetylcholinesterase (AChE) enzyme to prevent the breakdown of ACh.17,18 In general, an effective AChE inhibitor is typically characterized by three key structural features. This evidence concerns the gene ACHE and Alzheimer disease.