Further, TNFR1 mediated 30.7% of the negative association between hypertension or CVD and naïve CD4T cells independent of IL-6, while IL-6 mediated 12.1% of the association independent of TNFR1, although statistical significance for these mediation paths was weaker due to the slight overall association (p = 0.084 for TNFR1, p = 0.180 for IL-6). Here, IL6 is linked to hypertensive disorder.