GZMB and neoplasm: Given that CCR5 and CXCR6 are involved in T cell migration and retention within tumor tissues30–33, and that granzyme B (Gzmb) is a key effector molecule for cytotoxic function34, these findings suggest that as tumors progress toward a mesenchymal-like EMT state, they impair both the recruitment and functional activity of cytotoxic T cells, contributing to a less immunogenic tumor microenvironment.