Suppression of IFN signaling of SAMHD1-defective HEK293T cells by baricitinib, a JAK1/2 inhibitor, alleviated the repression of SARS-CoV-2 replication, suggesting that SARS-CoV-2 exploits SAMHD1 for IFN antagonism, thereby facilitating its infection [32]. The gene discussed is SAMHD1; the disease is infection.