These included genes linked to Fraser syndromes (Fras1, Frem2, Grip1), osteogenesis imperfecta and related bone fragility (Bmp1a, Col1a1, Col1a2, Col2a1), skeletal dysplasia (Fgfr3, Flnb, Nek1, Ebp), limb and heart malformations (Tbx5a), and cutaneous or connective tissue disorders (St14, Lmna, Pex1, Aspa). Here, PEX1 is linked to connective tissue disorder.