FREM2 and dysplasia: These included genes linked to Fraser syndromes (Fras1, Frem2, Grip1), osteogenesis imperfecta and related bone fragility (Bmp1a, Col1a1, Col1a2, Col2a1), skeletal dysplasia (Fgfr3, Flnb, Nek1, Ebp), limb and heart malformations (Tbx5a), and cutaneous or connective tissue disorders (St14, Lmna, Pex1, Aspa).