POLE and cancer: R192Q or Jmjd1b−/− mutation signature was also moderately similar to the SBS44 signature previously detected in human cancers associated with mismatch repair gene deficiency (Supplementary Table S4 and S5, Supplementary Figure S12), but limited similarity to the SBS20 or SBS10a/b signatures, which were associated with Polδ or Polε mutations, respectively (Supplementary Figure S12, Table S4, S5).