TRPA1 and osteoarthritis: Similar to our finding that trpa1b knockout reversed CBD thermal sensitization and revealed an antinociceptive effect of CBD on noxious heat (37.5°C) aversion, a previous study found that treatment with an antagonist of Trpa1 could attenuate CBD-mediated thermal hyperalgesia, and accentuate CBD-mediated analgesia, in a rat model of osteoarthritis (Mlost et al., 2021).