CD4 and infection: Janini Janini M. M. ,  Rogers Rogers M. M. ,  Birx Birx D. R. D. R. ,  McCutchan McCutchan F. E. F. E. ,  Human immunodeficiency virus type 1 DNA sequences genetically damaged by hypermutation are often abundant in patient peripheral blood mononuclear cells and may be generated during near-simultaneous infection and activation of CD4(+) T cells Human immunodeficiency virus type 1 DNA sequences genetically damaged by hypermutation are often abundant in patient peripheral blood mononuclear cells and may be generated during near-simultaneous infection and activation of CD4(+) T cells .