In one of the largest nodules involving DNA methylation, intermediate filament-based process, ncRNA metabolic, keratinocyte differentiation and epidermal cell differentiation process involve the upregulation of KRT family of proteins, MSX1, germline factor DDX4, mitotic checkpoint CHFR, and INHBB whose expression is associated with immune infiltrates in gastric cancers [40–42]. This evidence concerns the gene DDX4 and gastric cancer.