PRNP and Alzheimer disease: Specifically, Aß/PrPC complexes acting with mGluR5 as a co-receptor impair long term potentiation in hippocampal slices, trigger Fyn, Pyk2 and eEF2 kinase activity, increase phosphorylated Tau accumulation, disrupt the neuronal transcriptome, recruit C1q to damaged synapses, mediate synapse loss and lead to impaired spatial and object recognition memory in multiple mouse AD models 21, 22, 23, 24, 25, 26, 27, 28, 29, 30.