The observed downregulation of primary cilia stability gene SAXO1, and motile cilia function genes LCA5L, CFAP45, and DNAI7, as well as hypomethylation of the downstream cellular regulators GLI4 and GAS7, would further hint towards downstream disruption of Shh signaling and possibly, GI motility, in synucleinopathy patients. The gene discussed is GLI4; the disease is synucleinopathy.