CDK16 and synucleinopathy: We also observed hypomethylation in promoter regions of several genes implicated in autophagy, lysosomal trafficking, and stress signaling, such as CDK16, SH3GLB1, and ABCB9 in the synucleinopathy appendix (49) (50) (51), and hypermethylation of DCUN1D1, which was previously identified as a novel candidate gene in protein interactome-based PD studies (52).