Based on our previous findings and other recent literature linking alpha-synuclein aggregation propensity (27), aberrant gene regulation (28), and truncation (29) to propagation of pathology, we hypothesized that aberrant gene regulation in appendices of certain individuals facilitates accumulation of pathogenic alpha-synuclein and thereby increases risk of developing synucleinopathy. This evidence concerns the gene SNCA and synucleinopathy.