PIEZO1 is critically important for shear-stress induced Ca2+ signaling in endothelium (Li et al., 2014a), for lymphatic valve and vessel development (Nonomura et al., 2018; Choi et al., 2019; Choi et al., 2024) and for hypertension-dependent arterial wall remodeling (Retailleau et al., 2015). The gene discussed is PIEZO1; the disease is Hypertension.