The HBEC-5i cells also exhibit high-abundance expression of key proteins that are critical to the establishment of cancer cells in the TME, such as adhesion (CDH5, VCAM1/CD106, ICAM1/CD54), transport (ABC transporters), and tight junction (CLDN5, OCLN) proteins, as well as receptors critical to modulating immune and inflammatory responses (TNF receptor CD40) (ATCC, n.d.). Here, CDH5 is linked to cancer.