Using traditional non-omics approaches (laboratory tests) and comparing statistical analysis, the following diagnostic biomarkers for sarcoidosis have been identified and validated: serum soluble interleukin-2 receptor (sIL-2R) 6–13, urinary U-8-OHdG 14–16, serum angiotensin-converting enzyme (ACE) 6,7,11,12, serum chitotriosidase 17–19, serum KL-6 20,21, serum CRP 11,21, and serum BNP 22,23. This evidence concerns the gene ACE and sarcoidosis.