As depicted on the volcano plot (Figure 2B), the most downregulated protein in sarcoidosis was calpain-1 catalytic subunit (P07384, log2FC, −4.9 and log10P, 14.9), followed by acyl-CoA-binding domain-containing protein 6 (Q9BR61, log2FC, −3.6 and log10P, 6.5). The gene discussed is ACBD6; the disease is sarcoidosis.