A support for our inference is the observation that the expression levels of EGLN3 and EGLN1 increase under hypoxic conditions in preparation for HIF-1α degradation upon the return of normal oxygen levels.31 Another supportive evidence is the observations in the literature demonstrating that the expression of HIF-1α could be modulated through histone demethylation mediated by KDMs.22, 34, 35 Specifically, the depletion or inactivation of KDM4A and KDM5B has been linked with the downregulation of HIF-1α and attenuation of tumor aggressiveness.22, 34. Here, KDM4A is linked to neoplasm.