Among the 12 DDM DEGs from JIB-04 treatment of MCF-7 that showed opposite expression changes in TCGA analysis of breast cancers vs. normal breast tissues, 6 were upregulated (SH2D3A, JAG1, DUSP1, HOXA4, JAM2, DENND5A) and 6 were downregulated (RHBG, FAM72D, ATP6AP1L, ZNF233, H2BU1, PLPP6) in MCF-7 cells upon JIB-04 treatment (Figure 7, middle panels). The gene discussed is HOXA4; the disease is breast cancer.