Such mutations, including hotspots in SF3B1 and U2AF1 and loss-of-function events in FUBP1, RBM5, RBM10, and ZRSR2, are recurrent in myelodysplastic syndromes, acute myeloid leukemia, chronic myelomonocytic leukemia, and multiple solid tumors (Fig. 6b)8,42–45. The gene discussed is SF3B1; the disease is chronic myelomonocytic leukemia.