Such mutations, including hotspots in SF3B1 and U2AF1 and loss-of-function events in FUBP1, RBM5, RBM10, and ZRSR2, are recurrent in myelodysplastic syndromes, acute myeloid leukemia, chronic myelomonocytic leukemia, and multiple solid tumors (Fig. 6b)8,42–45. This evidence concerns the gene U2AF1 and acute myeloid leukemia.