In contrast, mutant SRSF2 binds CCNG-rich ESE motifs more tightly and GGNG motifs more weakly, driving genome-wide inclusion of CCNG-containing cassette exons and exclusion of GGNG exons in both experimental models and primary MDS/AML samples [28, 34, 49–51]. This evidence concerns the gene SRSF2 and myelodysplastic syndrome.