Changes in mRNA abundance observed during infection strongly corresponded to those observed upon TMP treatment of infected cells (Rs = −0.57, Figure 5I), which indicated that the temporal overexpression of PABPC1 can reverse the reduction of cytoplasmic host mRNAs during infection, as expected if limiting PABPC activity causes degradation of host mRNA during infection. The gene discussed is PABPC1; the disease is infection.