SH2D3A and infection: An intriguing possibility is that limiting PABPC enables the virus to use preferential PABPC binding to its own mRNAs to promote degradation of short-tailed isoforms of pre-existing host mRNAs, while nsp1-mediated degradation neutralizes newly transcribed host mRNAs, which have longer poly(A)-tail lengths and include those transcribed in response to infection.