Several genes that encode proteins involved in cancer invasion and related to EMT, such as IGFBP2, VGF, and SMYD3, were robustly expressed in metastasis-specific clusters, whereas adrenergic-related genes (CHGA, ROBO2) were more highly expressed in the differentiated cell state within NB tumor cell continuum (Fig. 1I and Supplementary Fig. S2B). Here, IGFBP2 is linked to cancer.