The original authors found that two patterns emerged as correlated or anti-correlated with dysplastic progression: pattern 2, associated with KRAS signaling and proliferation and increasing in weight from normal epithelium to low and high grade PanIN, and pattern 7 (referred to here as the “PDAC-EMT pattern”), enriched in inflammatory and EMT signaling, correlated with cancer-associated fibroblast (CAF) density, and decreasing in weight as the grade of dysplasia increased14. The gene discussed is KRAS; the disease is cancer.