From this analysis, we confirm that IPMN-estrogen pattern 5 represents a transcriptional phenotype common to pancreatic precancer subtypes, namely the IPMN-PDAC cluster from the original cohort and high grade PanIN, while the GNAS mutation-associated IPMN-glycolysis pattern 3 is unique to IPMN. Here, GNAS is linked to pancreatic intraductal papillary-mucinous neoplasm.