The finding of this gene enriched in this population of cells of AJ BMS lungs is intriguing since PLXN4 has been reported to be upregulated in a cohort of patients with refractory asthma (65), as well as being found to be a locus associated with low FEV1 in asthmatic patients by GWAS (66). Here, PLXNA3 is linked to asthma.