Giannoni et al. [33] demonstrated that co-culture of bone-marrow stromal cells with CLL cells halts this process: key markers of mature osteoblasts (RUNX2, osteocalcin) fall sharply, and inhibitors of osteoblastogenesis (DKK-1, osteopontin) rise. The gene discussed is SPP1; the disease is B-cell chronic lymphocytic leukemia.