PIEZO1 and open-angle glaucoma: Previous studies have linked variants in PIEZO1 to PCG in children and POAG in adults, and administration of a PIEZO1 agonist, Yoda1, reduced IOP in mice, while the inhibitor GsMTx4 significantly decreased outflow facility [17], although neither small molecule is tissue specific and previous studies did not differentiate between TM- and SC-driven effects.