In mice, knockout studies have suggested that this pathway is less important than paracrine ANGPT1 signaling for SC development, but ANGPT2 variants are associated with glaucoma in humans and a variant in the 3’UTR of ANGPT2 that increases ANGPT2 expression leads to increased SC size in mice and is associated with reduced POAG risk in humans, suggesting that ANGPT2 has a significant functional role [12]. Here, ANGPT2 is linked to open-angle glaucoma.