BRDT and esophageal squamous cell carcinoma: In the ESCC cell line KYSE180, BRDT and BRD4 are colocalized at super-enhancer regions that regulate expression of migration-associated protein KRT14.30 We found that both MZ-1 at 1 μM and (+)-JQ1 at 10 μM decreased KRT14 levels by about 70% after 24-hour incubation in KYSE180 cells (Figure 5c; Supplementary Figure S12a).