To validate these distinct inflammatory patterns, we compared IS values of archetypal HRD tumors harboring BRCA1/2−/− alterations with HRP tumors; the differences were significant in both groups (Figure 2A; Z-score transformed IS comparison in dHpC p = 0.021, t = 2.3, in dCpH p = 0.027, t = −2.3; t-test), confirming that the interplay between HRD and inflammation is highly tumor-type specific. The gene discussed is BRCA1; the disease is neoplasm.