Consistent with a chronic inflammatory state, VEGF signaling and VEGFA expression were upregulated in HRD tumors (Figure 5G; Figure S7C), expanding prior findings in BRCA1-deficient murine ovarian models to a broader spectrum of HRD and gynecological cancers 9,87. The gene discussed is VEGFA; the disease is hypoparathyroidism-retardation-dysmorphism syndrome.