Analogously, among 775 glioblastoma patients in COSMIC, non-synonymous mutations in TP53, IDH1, PIK3CA, BRAF, and ATRX are significantly young-age biased relative to exome-wide synonymous mutations, but this is not so for PTEN and EGFR (Figure 4E). The gene discussed is TP53; the disease is glioblastoma.