Interestingly, although the AppNL-G-F female mice did not develop colon tumors, genes associated with cancer development and mesenchymal-to-epithelial transition (EMT) were significantly altered when AOM/DSS-treated colon tissues in AppNL-G-F female mice were compared with normal colon tissues from APP wild type mice (Fig. 3F). The gene discussed is APP; the disease is infectious otitis media.