SMAD5 and Alzheimer disease: Positive contributors included neuronal differentiation factors (NEUROD6, ATOH7, PEG3, CRYM, SUB1), many reduced in AD [73–75], while negative contributors—FOXJ1, ZHX3, JDP2, ZIC4, SMAD5—represent stress or developmental repressors whose strengthened inverse associations with NPTX2 protein in AD point to an emerging repressive transcriptional environment [76–79].