NPTX2 and Alzheimer disease: SERTM1 likewise decorrelated at the transcript layer (0.53 → 0.32) with slight RNA–protein over-correlating (0.24 → 0.26); separation rose from D = 0.78 to D = 1.00, moderate to strong, consistent with concurrent reductions of SERTM1 RNA and NPTX2 protein in AD (Fig. 3N and 3O).