The finding in this paper that blocking the binding of CD44 to HA improves pathology in a likely neutrophil-dependent manner is relevant to pulmonary immune diseases that are characterized by dysregulated HA matrices such as influenza and RSV.[15,65] Further experiments might include characterizing COVID-19 severity and neutrophil adhesion in our model after blocking HC•HA formation. This evidence concerns the gene CD44 and COVID-19.