We estimated the activities of protein kinases and transcription factors (TFs) based on the relative abundance of known targets in phosphoproteomics and transcriptomics data from 85 lung squamous cell carcinoma tumours in the CPTAC consortium (Fig. 4j), which can be directly compared to ubiquitinomes measured on the same samples62. The gene discussed is WEE1; the disease is squamous cell lung carcinoma.