A further six modules were shared between COVID-19 and PTB including module 34 which was enriched for antimicrobial humoral responses (DEFA1, DEFA3, RNASE3, BPI, PGLYRP1, CAMP, AZU1, ELANE and LTF) and neutrophil degranulation70 in the Reactome database (DEFA1, ORM1, ORM2, RNASE3, ATP8B4, STBD1, BPI, PGLYRP1, TCN1, MS4A3, ABCA13, CLEC5A, CAMP, AZU1, CPNE3, CEACAM8, ELANE, CEACAM6, CRISP3, LTF, PLD1, MMP8, CHIT1, LCN2, OLR1 and SLC2A). Here, DEFA3 is linked to COVID-19.