Specifically, their clusters 7, 8, 9, and 10 that are increased in AD patients and three of which correlated with beta-amyloid deposition in post-mortem tissue, are all significantly overlapping with PRDM1 KD positive DEGs (P value for Cluster 7: 3.9·10−6, Cluster 8: 1.1·10−10 Cluster 9: 1.5·10−6, Cluster 10: 1.4·10−10 Fisher’s exact test, Table S5). Here, PRDM1 is linked to Alzheimer disease.